Silent Information Regulator Proteins, Saccharomyces cerevisiae

A set of nuclear proteins in SACCHAROMYCES CEREVISIAE that are required for the transcriptional repression of the silent mating type loci. They mediate the formation of silenced CHROMATIN and repress both transcription and recombination at other loci as well. They are comprised of 4 non-homologous, interacting proteins, Sir1p, Sir2p, Sir3p, and Sir4p. Sir2p, an NAD-dependent HISTONE DEACETYLASE, is the founding member of the family of SIRTUINS.

Year introduced: 2003

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Tree Number(s): D12.776.354.750.750, D12.776.660.820

MeSH Unique ID: D038281

Entry Terms:

• Silent Information Regulator Proteins, S cerevisiae
• SIR Proteins, S cerevisiae
• Silent Mating Type Information Regulator Protein, S cerevisiae

See Also:

• Sirtuins

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Fungal Proteins
Saccharomyces cerevisiae Proteins
Silent Information Regulator Proteins, Saccharomyces cerevisiae

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Nuclear Proteins
Silent Information Regulator Proteins, Saccharomyces cerevisiae